Following is an excerpt from the 2nd edition of “Subconscious Restructuring” and “Reprogramming the Overweight Mind”

Disclaimer: This page is provided for educational and informational purposes only. The information provided on this page should not be used to diagnose or treat a health problem or disease. Always seek the advice of your doctor or another qualified health provider regarding a medical condition. This content or its use creates no physician-patient relationship. For example, stopping an antidepressant or PTSD medication should only be done under the prescriber's supervision. This also applies to supplementation. If under the age of 18, nothing in this article should be implemented without the supervision of a parent or MD.

SR™ Bacteriotherapy: The Apex of Emotional, Physical, and Aging Health

Bacteriotherapy is exactly what it implies. It is the use of bacteria (probiotics) as a therapeutic measure to correct gut dysbiosis along with the myriad of other psychophysiological issues it represents. Thoroughly revised estimates show that the typical adult human body consists of about 30 trillion human cells and about 38 trillion bacterial cells [195]. I am certain this will continue to be updated. The bottom line is that the human body has many more bacterial cells than human cells, which makes for a complex balancing act when attempting to correct a bacterial (gut microbiota) imbalance.

The symptoms of a microbiota disruption are wide and varied and affect each person differently. If oxalate poisoned, it is difficult to determine what is directly caused by oxalate dumping and what results from dysbiosis. Whatever the case, the damaged microbiota must be repaired, and this requires a systematic, focused effort. This is where the Inulin Probiotic HRW Protocol comes in. After well over a decade of first discovery and then research on how to reestablish microbial balance in the gut, I found the Inulin Probiotic HRW Protocol to be far and away the most effective. This is not to say that everything else in Step 6 does not need to be followed because it absolutely does, especially testing for vitamins and minerals that have been depleted because of dysbiosis and possible damage to the mitochondria. This protocol is, however, a critical first step to clear the head and establish the energy to recover as quickly as possible.

All symptoms listed below have either abated or are in the process of abating after 6 weeks on the Inulin Probiotic HRW Protocol. The microbiota is still being damaged from oxalate dumping, but repair is immediate with this protocol, and symptoms that have not resolved are not remotely as severe. Two of the most disturbing symptoms were impaired vision and hearing, which started to come back at six weeks.

Symptoms From My Oxalate Infection

  • Gallbladder and Liver Stones
  • Bile Sludge
  • Candida Overgrowth
  • Hallucinations
  • Paranoia
  • Poor Sleep
  • Suicidality (Suicidal Thoughts)
  • Exhibited symptoms of ALS, Parkinson's, Alzheimer's, Aphasia, and Multiple Sclerosis
  • Vertigo
  • Neuromyelitis Optica
  • Seizures
  • Tremors
  • Skin Peeling off Lips
  • Severe Gait Abnormalities
  • Axon Loss and Demyelination
  • Arrhythmias
  • Periodontitis
  • Severe Chronic Fatigue
  • Severe Brain Fog
  • Plaque Build-Up on Lower Front Teeth
  • Itchy Skin
  • Large Amounts of Oxalate Crystals From My Eyes
  • Excessive Ear Wax
  • Dry Cough
  • Itchy Throat
  • Constipation
  • Diarrhea
  • Stiff Neck, Shoulder, Back, and Big Right Toe
  • Ringing in the Ears (Tinnitus)
  • Dizziness, Poor Balance
  • Hyper Sensitivity to Light, Noise, and Odors
  • Interstitial Cystitis (Bladder Pain)
  • Enlarged Prostrate
  • ED

The Inulin Probiotic HRW Protocol: Gut Microbiota Remodeling

Remodeling the microbiota involves multiple steps, and we start with the Inulin Probiotic HRW (Hydrogen-Rich Water) Protocol because Inulin Probiotics and HRW are considered GRAS (Generally Recognized as Safe) by the Food and Drug Administration. However, the literature overview shows that, although the vast majority of probiotics are generally regarded as safe and beneficial for healthy individuals, caution is needed in selecting and monitoring probiotics when administering them to patients with compromised immune systems, leaky gut, or critical illnesses [198].

Even if you are not infected with oxalates, you will still benefit from the Inulin Probiotic HRW Protocol if you have any microbiota disruption, are experiencing any malaise, or are over the age of 40.

Fiber: The Biggest Lie Told by Carnivores

To be fair, the largest amount of nutritional information put out in the carnivore community is accurate, but stating that humans do not need fiber is horribly inaccurate. The argument against fiber is there is no RDA for fiber, and fiber has no nutrient value. Both statements are true. However, this does not take into consideration the nutrients that are produced by gut microbes eating the fiber or the myriad of other health benefits, as you will see below.

If one is suffering from a disrupted microbiota, which is consistent with oxalate poisoning, one must be very specific about the type and amount of fiber you eat. It is a crap shoot for anyone to tell you to eat more fiber or to go on a low FODMAP diet. Simply eating more fiber can cause you to ingest what poisoned you and caused the disruption in the first place, and going on a low FODMAP diet will impair your ability to heal. Getting this right is especially important when transitioning to a flexible carnivore diet because of the potential for oxalate dumping and severe malaise. Inulin from Jerusalem Artichoke by Micro Ingredients is 2.6 grams of fiber per 2.6-gram scoop, which is approximately one teaspoon. Inulin from the following is rated per 100 grams.

  • Garlic, 9–16 g
  • Raw Asparagus, 2–3 g
  • Raw Onion Pulp, 1.1–7.5 g
  • Wheat, 1–3.8 g
  • Raw Barley, 0.5–1 g

You would have to eat a considerable amount of these foods to equal what you can get in inulin powder, plus you are subject to the plant toxins that accompany them. It simply makes sense to separate the fiber from the plant, and this is exactly what one does with inulin powder.

Inulin

Warning: Inulin is a high FODMAP food (explained below), which means it can cause gastrointestinal distress if used in excess. Inulin is a fructan-type oligosaccharide that's found in many plants, which represents the O in FODMAP. This is a dichotomy because this high FODMAP fiber is instrumental in remodeling the gut. Yet, if you have gastrointestinal issues, you will immediately be told to avoid high FODMAP foods. Slowly introducing inulin is critical. This is one of many cases where you absolutely do NOT want the whole food, as you will see below.

Benefits of Inulin

  • Consuming inulin alters the colon epithelium by increasing the proliferation of intestinal stem cells, leading to deeper crypts and longer colons. Inulin affects the activity of intestinal stem cells and drives a homeostatic remodeling of the colon epithelium [190], [167].
  • In a rat model, 24-hour urinary oxalate excretion significantly decreased in the inulin group compared with the control [185].
  • The gut microbiome responds to inulin treatment and exhibits significant structural alterations [186].
  • The concentration of inulin increases, the rate of oxalate degradation [215].
  • Inulin use inhibits harmful bacteria or opportunistic pathogens by promoting the proliferation of beneficial bacteria. In addition, pathogenic bacteria tend to colonize the intestine in an alkaline environment. Inulin lowers intestinal pH after enterobacterial fermentation, which also contributes to the inhibition of pathogenic bacteria [186].
  • Dietary supplementation with inulin can restore the integrity and function of the intestinal barrier by promoting the expression of zonula occludens [186].
  • Inulin treatment promotes the growth of certain beneficial bacteria and bacteria that promote the production of SCFAs (short-chain fatty acids), such as Bifidobacterium [186].
  • SCFAs can act locally in the intestine and be used as energy sources by intestinal mucosal cells to promote barrier function, maintain mucosal immunity, and provide energy substrate for colonic cells. SCFAs can also enter the circulation through the hepatic portal vein and act as signaling molecules, thereby regulating systemic immune function [186].
  • Inulin supplementation decreased the relative abundance of Bacteroidetes and increased levels of Bifidobacterium spp., Anaerostipes spp., Enterococcus Faecalis, and Lactobacillus. Inulin also promotes an increase in the abundance of bacteria of the genera Phascolarctobacterium, Blautia, Akkermansia, Ruminococcus, and the family Lachnospiraceae, which are also responsible for SCFA production [186].
  • Inulin can regulate the metabolism of glucose, lipids, and amino acids in addition to intestinal immune and systemic immunomodulatory effects.
  • Inulin can improve the symptoms of many diseases, such as metabolic syndrome, IBD, and chronic kidney disease (CKD), associated with intestinal inflammation and intestinal dysbiosis, as well as allergic diseases and tumors related to immune imbalance [186].
  • Inulin intake modulates ecological dysbiosis, reduces the level of fasting glucose, attenuates insulin resistance, and improves lipid disorders [186].

Inulin-Responsive Bacteria in the Gut Microbiota

This is the probiotic information you need after someone tells you to eat more fiber. I will drill down on Faecalibacterium and what I consider to be the Fantastic 4 probiotics, with a comprehensive overview of L. Reuteri, L. Gassier, L. Acidophilus, and B. Longum at the bottom. These are all oxalate degraders and will drive home the importance of Inulin. The following are inulin-responsive probiotics and are listed in order of responsiveness to inulin [187]. I personally have not found a probiotic that is not responsive to inulin. This is why it is also used in our yogurt-making process.

  1. Phocaeicola (Bacteroidaceae)
  2. Faecalibacterium (Ruminococcaceae)
  3. Hydrophilic
  4. Hydrophobic
  5. Agathobacter (Lachnospiraceae)
  6. Streptococcus (Streptococcaceae)
  7. Bacteroides (Bacteroidaceae)
  8. Prevotella (Prevotellaceae)
  9. Blautia (Lachnospiraceae)
  10. Fusicatenibacter (Lachnospiraceae)
  11. Ruminococcus (Ruminococcaceae)
  12. Lachnospiraceae spp.
  13. Roseburia (Lachnospiraceae)
  14. Bifidobacterium (Bifidobactericeae)
  15. Lachnospira (Lachnospiraceae)
  16. Dialister (Veillonellaceae)
  17. Dorea (Lachnospiraceae)
  18. Alistipes (Rikenellaceae)
  19. Faecalibacillus (Erysipelotrichaceae)
  20. Gemmiger (Ruminococcaceae)
  21. Mediterraneibacter (Lachnospiraceae)
  22. Kineotrix (Lachnospiraceae)
  23. Coprococcus (Lachnospiraceae)
  24. Parasutterella (Sutterellaceae)
  25. Lactococcus (Streptococcaceae)
  26. Ruminococcaceae spp.
  27. Parabacteroides (Porphyromonadaceae)
  28. Ruminococcus spp.
  29. Collinsella (Coriobacteriaceae)
  30. Clostridium_XIVa (Lachnospiraceae)
  31. Mitsuokella (Selenomonadaceae)
  32. Agathobalocum(Ruminococcaceae)
  33. Paraprevotella (Prevotellaceae)
  34. Anerostipes (Lachnospiraceae)
  35. Dysosmobacter (Ruminococcaceae)
  36. Lactobacillus (Lactobacillaceae)
  37. Raoultibacter (Eggerthellaceae)

Faecalibacterium

  • Obese or T2D (type 2 diabetes) patients have lower microbiota diversity, and Faecalibacterium is one of the community members that has been found to differ. In other research, Faecalibacterium was enriched in T2D patients following weight loss. The same study found that samples from lean patients contained higher numbers of Faecalibacterium genes than did samples from obese and T2D patients [188].
  • Faecalibacterium is diminished in MDD (Major Depressive Disorder) patients, while an increase in Faecalibacterium improved MDD symptoms. This concludes that Faecalibacterium may be used as an important species for an effective response to depression treatment [189].
  • Numerous studies have underscored that low levels of Faecalibacterium are correlated with inflammatory conditions, with inflammatory bowel disease (IBD) in the forefront. Its representation is also diminished in the case of several diseases, including colorectal cancer (CRC), dermatitis, and depression. Additionally, the relative presence of this genus is considered to reflect, at least in part, intestinal health status because Faecalibacterium is frequently present at reduced levels in individuals with gastrointestinal diseases or disorders [188].

Faecalibacterium is just one of 37 species listed here. The bottom line is the use of inulin is a critical factor in remodeling the gut microbiota and overall emotional and physical health.

Inulin Safety: Under 40 grams daily is safe for healthy adults [186]. I currently do not exceed 5.2 grams daily. I am still slowly increasing.

Inulin Dosing: I recommend starting out very slow with 1/10th of a teaspoon of inulin in yogurt. Some people may need to do less, and some may need to do more. If you are making Extended Fermentation Yogurt, this must be taken into consideration because there is a big variable in the amount of inulin your starter uses. I will normally start my morning with one or two 15.5 ounces of HRW and then eat some of my homemade yogurts and mix the inulin with it. I did this until I worked up to 1 teaspoon of inulin daily. If you have a foul reaction from 1/10th of a teaspoon, you may be dealing with SIBO or SIFO. If you have SIBO, inulin may exacerbate this issue. If you have SIFO (candida overgrowth, etc.), inulin will help eradicate it. The instructions on the insulin package will tell you to mix it with water; however, this did not work for me. If one does not get this right, you can end up with record-setting gas.

Guar Gum: A Fiber to Stay Away From

Until a study in 2024, it was thought that guar gum was beneficial for the gut. In a mouse model, a Guar gum-containing diet (GuD) increased the susceptibility to colonic inflammation. Unfavorable changes in gut microbiota activity leading to compromised gut barrier function following guar gum feeding contributed to increased colitis susceptibility [232].

Probiotics: The Fantastic 4 

We are now in the age of choosing a probiotic based on what you want to fix or change in your body and mind, and L. Reuteri is a good example of this. However, this choice goes far beyond bacterial species. One must also choose the strain of species that most manufacturers do not include on their labels. BioGaia, for instance, is one of the few that lists the strains that they use. This, along with being the most researched from a human source, is one of the many reasons L. Reuteri is still at the top of my list after using it for over a decade.

Probiotic Species Compatibility

L. reuteri strains lacked robust inhibitory antimicrobial effects of bacterial pathogens when combined with other probiotic Lactobacillus species, such as L. acidophilus, L. Gasseri, and L. johnsonii. By contrast, L. reuteri potently inhibited L. casei, which highlights the importance of species compatibility considerations when creating mixed-species probiotic formulations [200]. What this means is that you must know your objectives. If you want to maximize the effectiveness of L. Reuteri, you must confirm that it does not conflict with any other probiotic in your probiotic formula. The same goes for Dr. Davis’s SIBO formula. L.  Reuteri should be made  and taken separately from L. gasseri.

In other cases, probiotics can work synergistically. L. acidophilus (strains NK1, K3III24, 100 ash), Bifidobacterium adolescentis MC 42, B. bifidum, and B. gallinarum GB synergistically produce lectins with antimicrobial activity against clinical strains of nystatin-resistant Candida albicans, S. aureus, and their biofilms [228]. Unfortunately, The Fantastic 4 must all be made and used separately.

Bacteriocins

Bacteriocins are ribosomal synthesized antimicrobial peptides produced by bacteria or, for our purposes, probiotics. They can kill or inhibit bacterial strains closely related or non-related to the bacteria themselves but will not harm the bacteria themselves through specific immunity proteins. Bacteriocins may become a potential drug candidate for replacing antibiotics to treat multiple drug-resistant pathogens in the future [204]. 99% of all bacteria probably produce at least one bacteriocin, most of which have not yet been identified because few researchers have looked for them [205]. We will, therefore, not attempt to give you the number of Bacteriocins per probiotic listed in The Fantastic 4 Probiotics.

Probiotics For Oxalate Degradation

In vitro, oxalate degradation does not reflect the ability of bacteria to metabolize oxalate in vivo after intestine colonization [207]. This statement was made during an extensive study on probiotics and various disease states, including oxalate degradation. However, oxalate degradation by Lactobacillus indicates that out of 60 strains tested from 12 different species, strains L. acidophilus, and L. gasseri were most efficient in their ability to degrade oxalate in vitro [211]. In other words, science is not yet definitive, and one must experiment to find what works for each species and strain, as I do. The in vitro, however, does at least point one in the right direction.

On my first comprehensive stool test, I scored a 10 out of 10 on Dysbiosis and Metabolic imbalance and a 7 on inflammation. If you have ever wondered what suicidality looks like in the gut, this first test is it. On my second comprehensive stool test, I brought those scores down to 0, 2, and 2, respectively. On the first test, all primary gut bacteria were deficient with Euryarchaeota Phylumbacteria, so low that it did not register. More on this below. Oxalobactor formigenes, which is a well-established gut bacterium that uses oxalates as fuel, were intact when tested. Because of the severity of my infection, this was not enough, and even taking up to 1.7 trillion CFU of the best probiotic I could find was not sufficient either. This was because the purging of oxalates was consistently disrupting bacteria that went far beyond what was tested. A study just released as I was finishing this paper confirmed the need for a broader spectrum of gut bacteria or effective bacteriotherapy when addressing the breakdown of oxalates [231].

Oxalate-Degrading Bacteria in Bifidobacterium and Lactobacillus [173]

  • Lactiplantibacillus plantarum 
  • Lactobacillus brevis
  • Lactobacillus acidophilus
  • Bifidobacterium infantis
  • Bifidobacterium animalis
  • Bifidobacterium breve
  • Bifidobacterium longum
  • Bifidobacterium adolescentis
  • Lacticaseibacillus casei            
  • Lactobacillus gasseri
  • Lactiplantibacillus plantarum
  • Lacticaseibacillus rhamnosus
  • Ligiactobacillus salivarius

What Makes the Fantastic 4 So Fantastic?

It is more than just getting the right species and strains of a probiotic; it is also about the dose or CFUs being right. We do this through extended fermentation of yogurt or whatever you are fermenting, usually for up to 36 hours. Dr. William Davis has done the most experimentation with this and found that going to 48 hours killed a lot of the bacteria. This may not be the case with all probiotics, but it was with L. reuteri 6475 and 19738. Dr. Davis was able to take 2 billion CFUs of 6475 and 19738 and turn them into 200 to 260 billion CFUs per half cup of yogurt. He measured this with flow cytometry. Flow cytometry is a lab test that uses lasers to analyze the physical and chemical characteristics of cells and particles. Without the use of extended fermentation, the effect of these probiotics may not even be noticeable.

The Fantastic 4 probiotics cover a broad range of issues, and I have tested them all. However, this science is still in its infancy, so expect even better results as it becomes more refined.

What The Fantastic 4 Have in Common

  • All 4 are human strains
  • All 4 are colonizing probiotics as opposed to transient
  • All 4 populate the upper and lower intestines
  • All 4 survive stomach acid
  • All 4 do not need refrigeration

Displacement of Possible Pathogens

Displacement of possible pathogens is one of the many reasons why I believe I felt better with all the Fantastic 4. Attachment to the intestinal mucosa is an essential factor associated with probiotics when there is intestinal inflammation. Some probiotic microbes also share binding sites with some entero-pathogens and could hinder their attachment to the host’s cells by binding to the respective attachment sites [228].

Stimulation of Bowel Microbiota

The gastrointestinal tract (GIT) is home to an organized microbial community (microbiota), which partake in metabolic, nutritional, biochemical, and immunological processes within the body. Hence, cell-to-cell interactions exist to regulate microbial multiplication and preserve intestinal homeostasis, leading to a range of host responses against commensal and pathogenic organisms. The microbiota is an active ecosystem that is affected by many factors, such as genetics, metabolism, nutrition, geographical location, stress, and antimicrobial treatment [228].

Stimulation of the Digestive Enzymes

Some probiotics aid in the breakdown of complex macronutrients and provide the host with digestive enzymes and vitamins, which enhance the absorption of nutrients. The ability of probiotics to promote lactose fermentation has made them useful in treating lactose intolerance in humans. Probiotics Bifidobacterium strains, such as B. longum, participate in the metabolism of oligosaccharides [228].

Aging

During aging, the gut microbiota undergoes alterations, and its mediated increase in intestinal permeability leads to chronic inflammation, decreased efficiency of DNA repair, stem cell depletion, and cellular senescence of the organism. Altogether, these processes contribute to aging [233].

The degeneration of brain function in the elderly is correlated with the risk of several diseases, such as stroke, delirium, Parkinson’s disease, Alzheimer’s disease, and chronic subdural hematoma. These diseases are inextricably linked to the gut microbiota [232]. Only by fully understanding the gut microbiota can we uncover deeper mysteries, with the aim of early understanding of its complex relationship with host aging. Unfortunately, we are not there yet, but I believe the Fantastic 4 represents a foundational approach to living a disease-free life at any age.

Other Probiotic Ingredients

There is no avoiding additional ingredients in commercial probiotics. Following are definitions of these ingredients. We do not include the capsule ingredients because they are thrown out when making extended-fermentation yogurt.

BioGia Gastrus Lactobacillus Reuteri 6475 and 17938 Other Ingredients

  • Isomalt: Isomalt is a sugar substitute used primarily for its sugar-like physical properties. It has little to no impact on blood sugar levels and does not stimulate the release of insulin.
  • Ascorbic Acid: Synthetic version of vitamin C.
  • Mint and Mandarin Flavor: Straight Forward

Mercola L. Gasseri Other Ingredients

  • Fructooligosaccharide (FOS): A plant sugar that is found in many fruits and vegetables and is also used as a prebiotic and alternative sweetener.
  • Ascorbyl Palmitate: An ester formed from ascorbic acid and palmitic acid, creating a fat-soluble form of vitamin C.
  • Silicon Dioxide: Silicon dioxide, also known as silica, is a natural compound made of two of the earth's most abundant materials: silicon and oxygen.

Now Lactobacillus Acidophilus La-14

  • Stearic Acid: Stearic acid is a saturated fatty acid that exists in plants and meat.
  • Silicon Dioxide: Silicon dioxide, also known as silica, is a natural compound made of two of the earth's most abundant materials: silicon and oxygen.

Just Thrive Bifidobacterium Longum 1714

  • B6: Natural Form
  • Folate: Natural Form
  • B12: Natural Form

Be aware that there are probiotic producers who use synthetic B vitamins, which I do not recommend.

Probiotics: The Fantastic 4

  1. Lactobacillus Reuteri ATCC PTA 6475 and DSM 17938

Primary Objective: Microbiota Balance

L. reuteri ATCC PTA 6475, which is an Isolate from Finnish mother’s milk, and L. reuteri  DSM 17938, which is the daughter strain of Lactobacillus reuteri ATCC 55730, is a bacteria originally isolated from the breast milk of a Peruvian mother. These are the two most researched L. Reuteri strains on the market. This does not imply they are the best, just the most researched. These two strains are sold as BioGaia Gastrus on Amazon.

Oxytocin: The Love and Empathy Hormone

Both L. Reuteri 6475 and 17938 produce oxytocin but within the gut. Oxytocin is normally produced in the hypothalamus (The area of the brain that controls body temperature, hunger, and thirst.), but L. reuteri is believed to inhabit the human small intestine predominantly and appears to have co-evolved with its other hosts. Oxytocin is a multifunctional hormone that affects not only social behavior, bone, and skin but also gut motility, inflammation, and the intestinal epithelial barrier. Therefore, L. reuteri signaling through oxytocin could potentially explain many of the systemic effects of this microbe [224].

In humans, intranasal administration of oxytocin was found to increase bonding-related behavior, including gaze-to-eye region, interpersonal trust, empathy, and social cognition. Oxytocin has also been shown to play a role in human parenting, and peripheral levels of oxytocin have been associated with reciprocal parent-infant interactions in both mothers and fathers [225].

The full effects of oxytocin are yet to be realized, and the fact that the gut can produce oxytocin via microbes brings up more questions as to the physiological and emotional systems it affects. One question that was not answered was whether oxytocin produced by microbes can communicate with the brain via the vagus nerve or if it is for gut benefits only.

  • L. reuteri 6475 counteracts a degradation of gut microbiota in older women with low bone mineral density [201].
  • L. reuteri 6475 prevented abdominal fat pathology and age-associated weight gain in mice regardless of their baseline diet [208].
  • In a mouse model, L. reuteri increased testosterone, testicular mass, and other indicators typical of old age were similarly restored to youthful levels [226].
  • L. reuteri 6475 has a beneficial effect on sperm concentration and sperm activity in 12-month-old outbred Swiss mice [226].
  • L. reuteri DSM 17938 had beneficial effects on people suffering from chronic constipation [202].
  • L. reuteri 6475 exhibited broad-spectrum antimicrobial activity [203].
  • L. reuteri 6475-derived histamine can suppress gut inflammation [206].
  • L. reuteri 6475 has anti-inflammatory and anti-infectious capacities [206].
  • L. reuteri 6475 can reduce the number and size of colon tumors [206].
  • L. reuteri DSM 17938 supplement improved bacterial diversity along with enriched Firmicutes (good bacteria) and reduced abundance of Bacteroidetes [211]. Bacteroidetes increase as obese mice lose weight. Furthermore, when the microbiota of obese mice are transferred to germ-free mice, these mice gain more fat than a control group that received microbiota from lean mice [229].
  • L. reuteri DSM 17938 Protected the mucosal barrier and reduced inflammatory factors [212].
  • L. reuteri DSM 17938 In both children and in adults, shortens the duration of acute infectious diarrhea and improves abdominal pain in patients with colitis or inflammatory bowel disease [213].
  • L. reuteri DSM 17938 upregulates oxytocin and downregulates cortisol [222].
  • L. reuteri restores gut microbiota balance, produces antimicrobial metabolites, regulates intestinal immunity, and mediates mucosal homeostasis, thereby exhibiting protective effects on digestive system diseases [211].
  • The symbiotic intervention of Lactobacillus reuteri and inulin protected gut barrier integrity and altered the gut microbiota composition, enhancing the abundance of butyrate-producing Bifidobacterium [197].
  • A symbiotic formulation of Lactobacillus reuteri and inulin alleviated Autism Spectrum Disorder-like behaviors in a mouse model [197].
  • Four weeks of Lactobacillus reuteri and inulin attenuated inflammatory cytokine expressions in the brain in a pig model [197].
  • L. Reuteri significantly reduces chronic functional abdominal pain in children [64.]
  • High-fat-diet-induced obesity is associated with decreased anti-inflammatory L. Reuteri [65].
  • L. Reuteri reduces hepatic cancer cell proliferation, muscle wasting, and morbidity and prolongs survival [66].
  • L. Reuteri attenuates stressor-enhanced infectious Colitis [67].
  • L. reuteri has antifungal effects on oral Candida species in vitro [199].

Where to purchase: Amazon.com

Tested: Yes

Administration: Extended Fermentation Yogurt

Probiotic Amount: Ground up 10 tablets into a powder to equal 2 billion CFUs for 24 ounces of half and half.

Half and Half: 24 ounces per 32-ounce bowl or 48 ounces per 8 yogurt jars

Inulin: 1 rounded tablespoon per 24 ounces or 2 rounded tablespoons per 48 ounces for 8 yogurt jars

Fermentation Time: 36 Hours

Optimal Temperature: 100°F

Actual Temperature: 100°F

Recommended Amount: Half Cup Daily

Therapeutic Amount: Over seven days, I ate one cup of yogurt twice daily, which amounted to approximately one trillion CFUs. I reduced this amount after 5 weeks for all strains.

Results: Even though there is no literature on the ability of L. reuteri Strain 6475 and 17938 to degrade oxalates, I did notice a considerable reduction in my oxalate dumping and a lessening of symptoms. There is oxalate-degrading evidence of other L. reuteri strains. The oxalate dumping symptoms finally became linear.

  1. Lactobacillus Gasseri BNR17

Objective: Body Composition

  • L. gasseri BNR17 Reduces Visceral Fat Accumulation and Waist Circumference in Obese Adults [214].
  • L. gasseri BNR17 was confirmed to have probiotic properties by reducing IBS symptom severity scores, especially in relieving abdominal pain [223].
  • In a 21-day mouse model, L. gasseri BNR17 showed a significant increase in lean body mass and a decrease in fat mass [227].

There are multiple strains of L. Gasseri that will degrade oxalates, but there is no literature on this specific strain. I did notice degradation in oxalate and a significant improvement in oxalate dumping symptoms.

Where to Purchase: Amazon.com

Tested: Yes

Administration: Extended Fermentation Yogurt

Half and Half: 24 ounces per 32-ounce bowl or 48 ounces per 8 yogurt jars

Inulin: 1 rounded tablespoon per 24 ounces or 2 rounded tablespoons per 48 ounces for 8 yogurt jars

Fermentation Time: 36 Hours

Recommended Temperature Range: 109°F

Actual Temperature: 109°F

Recommended Amount: Half Cup Daily

Therapeutic Amount: Over seven days, I ate one cup of extended fermentation yogurt twice daily.

Results: I continued to notice an improvement in oxalate dumping symptoms. The body composition test is 21 days, but my focus for now is oxalate degradation with La-14 and sleep with 1714.

  1. Lactobacillus Acidophilus La-14 and NCFM

Primary Objective: Oxalate Degradation

  • L. Acidophilus La-14, along with many other L. Acidophilus strains, has been shown to degrade oxalates up to 100% in vitro [216].
  • L. acidophilus La-14 exhibited not only the ability to break down oxalate but also may modulate the release of inflammation mediators associated with oxalate accumulation in the human gastrointestinal tract [217].
  • L. acidophilus exhibits an antifungal effect against Candida if harvested after prolonged incubation of 24 to 36 hours [218].
  • L. Acidophilus restrains the development of S. aureus and P. aeruginosa enteric infections [71].
  • Exopolysaccharides (EPS) from Lactobacillus acidophilus have antioxidative properties [72].
  • Surface layer protein A (SlpA) from Lactobacillus acidophilus NCFM potentially represents a feasible therapeutic approach to restore intestinal homeostasis [73].

Where to Purchase LA-14: Amazon.com

Tested: Yes

Administration: Extended Fermentation Yogurt

Probiotic Mix Amount: One Capsule to equal 2 billion CFUs per 24 ounces of half and half.

Half and Half: 24 ounces per 32-ounce bowl or 48 ounces per 8 yogurt jars

Inulin: 1 rounded tablespoon per 24 ounces or 2 rounded tablespoons per 48 ounces for 8 yogurt jars

Fermentation Time: 36 Hours

Recommended Temperature Range: 98.6°F to 107.6°F

Actual Temperature: 100°F

Recommended Amount: Half Cup Daily

Therapeutic Amount: Over seven days, I ate one cup of extended fermentation yogurt twice daily.

Results: I purchased La-14 specifically for oxalate degradation, and it delivered. After the second day, there was a significant difference in oxalates passed through the stool and a continued lessening of oxalate dumping symptoms.

  1. Bifidobacterium Longum 1714

Primary Objective: Sleep

The term psychobiotic is used more often with B. longum 1714 because of its effectiveness with depression and anxiety than any other probiotic listed here.

  • B. longum 1714 has been shown to influence stress responses, modulate neural responses during social stress, and influence sleep quality during examination stress in healthy adults [219].
  • B. Longum 1714 modulated neural activity, which correlated with enhanced vitality/reduced mental fatigue [219].
  • B. longum 1714 significantly improved the PSQI (Pittsburgh Sleep Quality Index) component of sleep quality [219].
  • B. longum assists in the regulation of the microbiota and helps to prevent IBD [220].
  • Preclinical studies have identified the B. longum 1714 strain as a putative psychobiotic with an impact on stress-related behaviors, physiology, and cognitive performance [221].
  • B. longum 1714 strain, which has shown anti-stress and procognitive effects in healthy mice, can also ameliorate both the physiological and psychological response to an acute stressor, as well as longer-term daily self-reported psychological stress, in healthy human adults [221].
  • B. Longum decreases the excitability of enteric (gut) neurons [83].
  • B. Longum has anti-allergy effects, reducing harmful bacteria, improving intestinal environment, defecation frequency, and improved stool characteristics [84].
  • B. Longum supplementation prevents bone loss and increases bone formation [85].

Where to Purchase 1714: Producers Website

This is an expensive probiotic, at 40 dollars on Amazon. The producer has a sample of 7 capsules for $17.99 with a 10% discount and $7.99 shipping, for a total of just under $25.00. When using it to make yogurt, you simply use one capsule to make the first batch and a couple of tablespoons of your current batch to make future batches, so 7 capsules are more than enough.

Tested: Yes

Administration: Extended Fermentation Yogurt

Probiotic Amount: One Capsule to equal 3 billion cells per 24 ounces of half and half.

Half and Half: 24 ounces per 32-ounce bowl or 48 ounces per 8 yogurt jars

Inulin: 1 rounded tablespoon per 24 ounces or 2 rounded tablespoons per 48 ounces for 8 yogurt jars

Fermentation Time: 36 Hours

Recommended Temperature Range: 96.8°F – 100.4

Actual Temperature: 100°F

Recommended Amount: Half Cup Daily

Therapeutic Amount: Over fourteen days, I ate one cup of extended fermented yogurt twice daily.

Results: I initially combined 1714 with LA-14, and it pushed the lids off the yogurt jars. I then fermented just 1714, and it did not push the lids off, but it did push the center of the lid up on the one-quart jars. 1714 is the only probiotic that did this. I also tried coconut milk, and it did not work; it remained liquid, and the cream separated, but there were chunks of coconut floating around, which is not recommended. Even with two ruined batches, I did notice a difference in sleep quality within 7 days.

1714 Sleep: Into the second batch, I took a nap and had the deepest sleep I have had in a long while. There is a question as to how long I will need to use this or any of these probiotics to achieve a permanent effect or if that is even possible. I split a batch, so I will make 1714 and La-14 to address sleep and oxalate degradation at the same time. When I feel like these issues are under control, I will switch to BNR17, 6475, and 17938. This process will be different for every person, depending on your objectives. Both oxalate dumping and candida die-off disrupt sleep, and I was hoping this probiotic would override this, and it did to a significant extent. I got my first hour of sleep in well over a year at the end of the second week. I am happy with what I was able to accomplish with this probiotic, and I have only been on it for 2 weeks when most studies were done over 4 weeks.

Other Probiotic Species to Consider

  1. Lactobacillus Rhamnosus
  2. L. rhamnosus exhibits an antifungal effect against Candida if harvested after prolonged incubation of 24 to 36 hours [218].
  3. Evaluation of L. rhamnosus confirmed that the oxalate degradation is more significant in the presence of glucose [210].
  4. Lactobacillus rhamnosus GG has been suggested to increase bone formation by stimulating the production of microbial metabolite butyrate, which induced T cell-produced Wnt10b in eugonadic young mice [201].
  5. L. Rhamnosus provides protective effects on alcoholic liver injury by reducing oxidative stress and restoring the intestinal flora [68].
  6. L. Rhamnosus diminishes oxidative markers in the brain [69].
  7. L. Rhamnosus protects against tissue damage mediated through free radicals and inflammatory cytokines [70].
  8. Lactobacillus Plantarum
  9. In a rat model, L. Plantarum exhibited oxalate degrading abilities in vitro [209].
  10. L. Plantarum could ameliorate anxiety and depression-like behaviors and modulate neurochemicals related to affective disorders [75].
  11. L. Plantarum potentially enhances the immunity of the small intestine [74]
  12. L. Plantarum positively affects the immune system and acts as an antiviral [76].
  13. Lactobacillus Brevis
  14. L. Brevis synthesizes gamma-aminobutyric acid (GABA) [77]. GABA is the most potent depressive neuroamine in human brains. It regulates many of the depressive and sedative actions in brain tissue and is critical to relaxation [78].
  15. L. Brevis may prevent some metabolic disturbances [79].
  16. Lactobacillus Casei
  17. L. casei exhibits an antifungal effect against Candida if harvested after prolonged incubation of 24 to 36 hours [218].
  18. Bifidobacterium Lactis
  19. B. Lactis improves the intestinal microbiota more effectively than non-proliferating bifidobacteria and lactic acid bacteria [80].
  20. B. Lactis improves defecation frequency [81].
  21. As part of a multispecies probiotic blend, B. lactis showed cognitive reactivity to sad mood, which was largely accounted for by reduced rumination and aggressive thoughts [82].

SIBO Yogurt

If you are suffering from SIBO, Dr. Davis recommends ATCC PTA 6475 and DSM 17938, L. gasseri BNR17, and bacillus coagulans gbi-30 6086. Bacillus coagulans is not included on this list because it is not considered a natural part of the human gut flora, and I am simply not impressed with it. I highly recommend you purchase Super Gut if you want to go beyond The Fantastic 4 or if you need to ferment other foods because of dairy sensitivity.

Yogurt Making: What I Use

Ultimate Yogurt Maker: This is the only one with a lifetime guarantee, which is a good thing because I am running it around the clock. I do, however, recommend doing your research. You can buy this yogurt maker with eight 6-ounce jars or two one-quart bowls. It is going to be 48 ounces for either one because you cannot max out the one-quart bowls without making a major mess.

2 Quart Measuring Cup: I use a large measuring cup as a mixing bowl so I can pour it directly into the 6-ounce jars when I am using those.

Extra Yogurt Bowls: I have one set of 6-ounce jars and two sets of one-quart Pyrex bowls. I got different colored lids to decipher which bowl had what strain. I also bought 6 one-cup Pyrex bowls to freeze the excess, as the 6-ounce jars are not freezer-compatible.

Baby Food Jars: I use the baby food jars to freeze yogurt, which I will want to use for a starter later. Inulin can be used as a cryoprotectant to protect the bacteria from getting damaged [230].

Hydrogen-Rich Water (HRW)

Water: Drinking filtered water is a no-brainer, but mineral and hydrogen water can also have profound effects.

Mineral Water: In a mouse model, kidney crystal formation and fibrosis were attenuated by drinking alkaline mineral water. Furthermore, alkaline mineral water also reduced kidney injury, cell apoptosis, oxidative stress, and inflammation [164]. I put this to the test by drinking mineral water only for three days. After the third day, I had the worst oxalate dump I had ever experienced, and by that time, I was halfway through the fifth year of a low oxalate diet. I now drink only mineral water at least three days a month and at every extended fast.

Hydrogen-Rich Water (HRW): Hydrogen is produced via gut bacteria (Primarily Bacteroides and Firmicutes), and if these bacteria are damaged or lowered, there is a host of physiological issues associated with it [171]. Hundreds of human and animal studies of hydrogen-rich water (HRW) exist. This first group of studies is from a systematic review that looked at human outcomes only. The second group will include animal studies.

HRW Human Studies Only

Benefits of HRW with Physical Exercise

  • HRW has shown antioxidant, anti-apoptotic, cytoprotective, and anti-inflammatory properties [165].
  • Hydrogen-rich water before exercising can mitigate the effects of fatigue and build endurance [165].
  • HRW administered pre-workout, which showed decreased blood lactic acid levels at a higher intensity and improved ventilatory efficiency [165].
  • HRW has been shown to reduce fatigue and improve endurance in the later stages of repeated sprints [165].
  • HRW can improve acidosis due to exercise, energy levels, and enhanced muscular performance in athletes [165].

Impact of HRW on Oxidative Stress

  • Hydrogen is effective against oxidative stress and is also known for its anti-inflammatory and anti-allergy benefits [165].
  • HRW decreases cellular and mitochondrial injuries [165].
  • Even at higher concentrations, hydrogen has no cytotoxicity [165].

Impact of HRW on Cardiovascular Health

  • Molecular hydrogen controls signal transduction and gene expression, suppressing pro-inflammatory cytokines and decreasing reactive oxygen species production [165].
  • HRW can potentially decrease LDL-C and apoB (a protein that helps transport lipids, like cholesterol, throughout the blood) levels while improving HDL function [165].
  • High-density lipoprotein (HDL) cholesterol increased by 8% [165].
  • The use of high-concentration HRW was shown to decrease blood glucose and cholesterol levels, improve serum hemoglobin A1c, and also to improve inflammatory biomarkers. Interestingly, it also led to an improvement in waist-to-hip ratio and body mass index [165].

COVID-19 and HRW

  • Molecular hydrogen therapies were also effective in remediating the dangerous consequences of COVID-19 infection [165].
  • Hydrogen administration inhibited cytokine cascade and decreased inhalation resistance in patients with mild to moderate disease [165].

Effect of HRW on Cancer

  • HRW has shown anti-cancer properties. With its antioxidant properties and ability to decrease oxidative stress, it could be a potential game changer in the future [165].
  • HRW was noted to have potential in treatment, overall prognosis, quality of life, and tumor reduction [165].

Benefits of HRW on Emotional (Mental) Health

  • Subjects who drank HRW for 4 weeks had improved mood, anxiety, and overall mood [165].

HRW and Liver Function

  • Liver dysfunction can be caused by inflammation, oxidative stress, and aberrant cellular signaling. It has been shown that the administration of hydrogen-rich water can have beneficial effects on these patients [165].
  • Hydrogen-rich water was shown to decrease fat accumulation in the liver and has the potential to be used as an adjuvant treatment for mild to moderate NAFLD (non-alcoholic fatty liver disease) [165].

Effect of Hydrogen-Rich Water on Aging

  • HRW has long-lasting antioxidant and anti-aging effects on vascular endothelial cells through the Nrf2 pathway (a cellular response to oxidative stress), even after transient exposure to H2 [165].

Hydrogen-Rich Water: In Vivo in Vitro and Animal Studies

Even though animal studies must be scrutinized much more than human studies, I never immediately discount them, especially if the subject is pertinent to my suffering.

  • HRW alleviates cellular senescence in endothelial cells [166].
  • Gene sequencing showed that HRW intake induced significant changes in the structure of gut microbiota. HRW intake mainly induced a significant increase in the abundance of Lactobacillus, Ruminococcus, Clostridium XI, and a decrease in Bacteroides [168].
  • In a rat model, HRW reduced constipation by modulating the microbiota [169].
  • HRW treatment decreased the levels of malondialdehyde (MDA) and Reactive Oxygen species (ROS) and significantly increased the activities of antioxidants [170]. For me, this was one of the biggest issues because purging oxalates left me incapacitated most of the time from severe poisoning.
  • HRW may be involved in the Gut-Brain interaction [171].
  • HRW Protects against Neurodegenerative Changes Induced by Traumatic Brain Injury [172].

Warning: I know this contradicts a previous human study, but while molecular hydrogen can interact with and enhance virtually every cell in the body and assist in remodeling the gut, it can also enhance the proliferation of cancer cells [176]. This is why a cancer screening and working closely with your MD are highly recommended before starting a hydrogen water protocol if you suspect you may have cancer.

Generating HRW: There are several ways to generate HRW. I use an HRW generator, and there are several things you should look for when purchasing one. Here are some attributes of the one I use, the Veemter 3 IN 1 Hydrogen Water Bottle Generator. I highly recommend doing your research before you purchase one. The specs of the one I use are below.

Size: 460 Milliliters (15.5 Ounces)

PPB (Parts Per Billion): The average is 1,500 PPB. The one I use has two modes: Push the button once, and you get 1,500 PPB; push the button twice, and you get 6,000 PPB. This is sometimes measured in PPM (parts per million), but this is an easy conversion: 1,000 PPB is 1 PPM. I could not find any third-party testing for this parameter.

SPE/PEM Technology: SPE and PEM refer to solid phase extraction and proton exchange membrane.

Platinum Titanium Core Electrolytic Sheet: I would not use any less than this.

Base Materials: The body of the hydrogen water bottle is made of high-quality food-grade borosilicate glass, and the lid is made of food-grade stainless steel.

3 Modes: This means you can generate HRW within the container, screw a water bottle to an accessory that is provided or breathe it. I do not use any of the accessories, and I do not drink out of the generator.

Results: I initially tried the single push of the button for 1,500 PPB of hydrogen with no issues, so I then tried the next mode and had a raging case of diarrhea for 24 hours. I returned to the single mode for two days and tried the 6,000 PPB mode again; the diarrhea only lasted a couple of hours. I now generate 2 to 6 15.5 ounces HRW daily in the 6,000 PPB mode. Once I got settled in, I started to feel better.

Inulin Probiotic HRW Assessment

I started Inulin and HRW two months before I implemented the extended fermentation yogurt (EFY) protocol. While I got good results with inulin and HRW, adding EFY amped it up significantly. I am very excited to see how far this will go. I still have significant oxalate dumping days, but I feel like I may have not only fixed the severe oxalate malaise but also discovered the fountain of youth, and I am not remotely close to being done.

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